Weight Loss · FDA-Approved GLP-1

The SHED Protocol

Semaglutide · GLP-1 Tirzepatide · GIP/GLP-1

Targets appetite and cravings at the source
Helps you feel full longer after meals
Shipped cold-packed from a licensed pharmacy

Weekly injection, subcutaneous · Refrigerate after receipt

Choose your starting dose

0.25 MG

$269/mo

0.5 MG

$299/mo

1 MG

$349/mo

$269 / month

FDA-approved brand medication

Prescription only Free shipping Provider review in 24h FDA-approved medication

Important safety information

Dual GLP-1/GIP action for enhanced results
FDA-approved, pre-filled weekly pen
Brand-name only — never compounded

Weekly injection, subcutaneous · Refrigerate after receipt

Choose your starting dose

2.5 MG

$289/mo

5 MG

$369/mo

10 MG

$429/mo

$289 / month

FDA-approved brand medication

Prescription only Free shipping Provider review in 24h FDA-approved medication

Important safety information

What It Is

FDA-approved weight loss — the real thing, not a compound.

Reduces hunger and cravings naturally
Helps you feel full longer after eating
Improves how your body processes sugar
May lower heart disease risk in eligible patients

Compare Your Options

Semaglutide

GLP-1 Agonist

Best for

The well-established option for steady, sustained weight loss

What's good

Targets appetite and cravings naturally
Slows digestion so you stay full longer
Gradual 5-step dose titration
Pause and resume anytime

Price$269/mo

Onset4-8 weeks

FreqWeekly

FormatPre-filled pen

$229/mo (save $40)

Tirzepatide

Dual GLP-1/GIP

Best for

Dual-action for those seeking enhanced metabolic response

What's good

Activates two receptors instead of one
May support stronger appetite control
Same weekly convenience
Emerging option for those who want more

Price$289/mo

Onset4-8 weeks

FreqWeekly

FormatPre-filled pen

$246/mo (save $43)

Featured Image images/shed-portrait.png

How it works

How Shed actually works.

Shed uses FDA-approved GLP-1 medications — semaglutide or tirzepatide — to regulate appetite, slow gastric emptying, and improve metabolic signaling. The same medications used in the landmark STEP and SURMOUNT trials.

Most patients see steady, sustainable weight loss starting around week four. Your provider follows you closely with monthly check-ins to titrate the dose and track progress in real terms, not just on a scale.

Shed Protocol · Semaglutide or Tirzepatide

Board-certified physicianslicensed in your state

Compounded by a US pharmacylicensed, audited, traceable

Free, discreet shippingincluded in your subscription

What You’ll Take

One injection per week.

Brand-name GLP-1 medication. Pre-filled pen, shipped from a licensed pharmacy. Not compounded.

Why This Protocol

FDA-approved, not compounded.

Branded semaglutide or tirzepatide from licensed manufacturers. The real thing, prescribed by a real physician.

About this protocol

Technical and clinical context our providers use when evaluating intake.

What are GLP-1 medications?

GLP-1 receptor agonist — mimics a natural hormone that controls appetite, insulin response, and how fast your stomach empties
Semaglutide or tirzepatide (dual GIP/GLP-1) — your provider matches the right one to your situation
Weekly self-injection via pre-filled pen
FDA-approved brand-name only. Never compounded. Provider follow-up at 4 and 12 weeks.
For people who want a clinically-managed metabolic approach — not a compounded shortcut

Storage & handling

Refrigerate at 36–46°F (2–8°C) before first use.
After first use, store at room temperature (up to 86°F) or refrigerated for up to 56 days (Semaglutide) or 21 days (Tirzepatide).
Do not freeze — discard if frozen.
Keep pen away from direct heat and sunlight.
Each pen comes with disposable needles.
FDA-approved — manufactured under strict pharmaceutical standards.

Your Weight Loss Arc

Week 1

First dose. Baseline weight logged. Appetite changes may begin.

Month 1

Dose increases gradually. Hunger drops noticeably. Early weight loss begins.

Month 3

Steady-state dosing. Significant weight reduction becoming visible.

Month 6+

Maintenance phase. Your provider helps you sustain your progress.

Your timeline to treatment

From personalized intake to ongoing support, we help you get — and stay — on track.

Start The SHED Protocol in 5 simple steps

Answer a few questions about your health, goals, and history — all online, no in-person appointment needed. You'll find out if you're eligible within 24 hours.

A US-licensed clinician reviews your intake, follows up on anything that needs clarification, and signs your prescription — typically within 24 hours.

A licensed clinician reviews your intake

Your Rx is filled with FDA-approved brand-name medication at a licensed US pharmacy and shipped directly to your door — cold-packed and sealed.

Licensed pharmacy dispenses your FDA-approved Rx

Your shipment lands at your door — refrigerated where required, with everything you need to start: vials, alcohol pads, syringes, and step-by-step guidance.

Ongoing care from our medical team — quick re-checks, dose adjustments when needed, and 24/7 access to your provider whenever a question comes up.

Sources & References

▾

Peer-reviewed research and regulatory documents our medical team consults when reviewing intake for GLP-1 protocols.

FDA / DailyMed

Wegovy (semaglutide) — Full Prescribing Information

FDA-approved label for branded semaglutide for weight management. Auto-updates from NIH DailyMed.
Novo Nordisk · revised March 2026

View source

FDA / DailyMed

Semaglutide — Full Prescribing Information

FDA-approved label for branded semaglutide for type 2 diabetes and cardiovascular/renal risk reduction.
Novo Nordisk · revised October 2025

View source

NEJM

STEP 1 — Once-weekly semaglutide in adults with overweight or obesity

Pivotal phase 3 trial (n=1961): 14.9% mean weight loss with semaglutide 2.4 mg vs 2.4% placebo at 68 weeks.
Wilding JPH, et al. — NEJM 2021

View source

JAMA

STEP 4 — Continued semaglutide vs placebo on weight-loss maintenance

Randomized withdrawal trial showing continued therapy maintains weight loss; switching to placebo causes regain.
Rubino D, et al. — JAMA 2021

View source

JAMA

STEP 8 — Weekly semaglutide vs daily liraglutide for weight loss

Head-to-head trial (n=338): semaglutide 2.4 mg −15.8% vs liraglutide 3.0 mg −6.4% at 68 weeks.
Rubino DM, et al. — JAMA 2022

View source

NEJM

SELECT — Semaglutide and cardiovascular outcomes in obesity without diabetes

Cardiovascular outcomes trial (n=17,604): 20% MACE reduction with semaglutide 2.4 mg in adults with established CVD and overweight/obesity.
Lincoff AM, et al. — NEJM 2023

View source

Lancet Diabetes & Endocrinology

SUSTAIN 1 — Once-weekly semaglutide monotherapy in type 2 diabetes

First pivotal phase 3a trial of subcutaneous semaglutide in treatment-naïve T2DM; HbA1c and weight reduction at 30 weeks.
Sorli C, et al. — Lancet Diabetes & Endocrinology 2017

View source

FDA / DailyMed

Tirzepatide — Full Prescribing Information

FDA-approved label for tirzepatide (GIP/GLP-1 receptor agonist) for chronic weight management.
Eli Lilly · revised 2024

View source

ClinicalTrials.gov

STEP 1 — Trial registry record (NCT03548935)

Official trial registry: protocol, endpoints, sponsor (Novo Nordisk), and result-reporting tied to the NEJM 2021 publication.

View source

Medical notice. The SHED Protocol uses FDA-approved GLP-1 medications prescribed only after clinical evaluation. Common side effects include nausea, vomiting, diarrhea, and constipation. Not appropriate for patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Risk of pancreatitis, gallbladder disease, and hypoglycemia when used with insulin. See full prescribing information. Statements on this page describe FDA-approved medications per their labeled indications.

Pairs With

What Shed stacks with.

The protocols our providers most often add alongside this one.

Metabolic Support · Lipotropic

Menu

Not sure where to start?

Take the quiz

Ready to lose weight?

Start here

Tired, sluggish, not yourself?

Take the assessment

Restore your confidence

Get started

Invest in your future self

Find your protocol

Clinically-proven regrowth

Start your protocol

Better rest starts here

Find what works

The SHED Protocol

FDA-approved weight loss — the real thing, not a compound.

Semaglutide

Tirzepatide

How Shed actually works.

One injection per week.

FDA-approved, not compounded.

About this protocol

Your timeline to treatment

Sources & References

Wegovy (semaglutide) — Full Prescribing Information

Semaglutide — Full Prescribing Information

STEP 1 — Once-weekly semaglutide in adults with overweight or obesity

STEP 4 — Continued semaglutide vs placebo on weight-loss maintenance

STEP 8 — Weekly semaglutide vs daily liraglutide for weight loss

SELECT — Semaglutide and cardiovascular outcomes in obesity without diabetes

SUSTAIN 1 — Once-weekly semaglutide monotherapy in type 2 diabetes

Tirzepatide — Full Prescribing Information

STEP 1 — Trial registry record (NCT03548935)

What Shed stacks with.

Burn

Rewind

Ignite